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Enter your email address below and we will send you your username Email or Customer ID Close If the address matches an existing account you will receive an email with instructions to retrieve your username COVID-19 Notice: How we support scientific communication and options for remote access to subscribed content JOURNALS The EMBO Journal EMBO Reports Molecular Systems Biology EMBO Molecular Medicine Life Science Alliance This Journal Anywhere Search journal Search Search EMBO Press Search Advanced search Citation search Login Close Drawer Menu Open DrawerJOURNALSClose Drawer Menu Open DrawerCurrent Issue About Aims & Scope Editors & Board Special Features of EMBO Press Open Access Licenses & Charges Journal Indicators Contact Editorial Office Information For Authors For Reviewers For Librarians/Subscribers For Media For Advertisers Archive Alerts Submit CURRENT ISSUE Inhibition of age-associated CIN delays senescense By Monika Barroso‐Vilares, Elsa Logarinho and colleagues Activation of inhibitory Gi‐coupled receptors potentiates the activity of the mechanosensitive ion channel Piezo2 through Gβγ and downstream protein kinases. This effect may contribute to the mechanical hyperalgesia induced by Gi‐coupled receptor activation. Gi‐coupled receptor activation potentiates Piezo2 currents via Gβγ John Smith Del Rosario Yevgen Yudin Songxue Su Cassandra M Hartle Tooraj Mirshahi Tibor Rohacs Activation of inhibitory Gi‐coupled receptors potentiates the activity of the mechanosensitive ion channel Piezo2 through Gβγ and downstream protein kinases. This effect may contribute to the mechanical hyperalgesia induced by Gi‐coupled receptor activation. Close Figure Viewer Browse All Figures Return to Figure Change zoom level Zoom in Zoom out Previous Figure Next Figure Caption Latest Online Current Issue Most Read Article 5 May 2020 The dual role of c‐src in cell‐to‐cell transmission of α‐synuclein Yu Ree Choi Jae‐Bong Kim Seo‐Jun Kang Hye Rin Noh Ilo Jou Eun‐Hye Joe Sang Myun Park This study reveals that c‐src promotes the release and uptake of α‐syn and that c‐src inhibition attenuates α‐syn cell‐to‐cell transmission, suggesting that c‐src‐targeting drugs might be repurposed for the development of Parkinson’s therapeutics. Article 3 May 2020 OPEN ACCESS ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids Srinath Govindarajan Eveline Verheugen Koen Venken Djoere Gaublomme Margaux Maelegheer Eva Cloots Fien Gysens Bruno G De Geest Tan‐Yun Cheng D Branch Moody Sophie Janssens Michael Drennan Dirk Elewaut Upon ER stress immunogenic lipids are produced that activate NKT cells. Defining the conditions required to generate endogenous high immunogenic lipid antigens paves the way for the design of novel lipids with immunomodulatory function. Science & Society 30 April 2020 OPEN ACCESS Gender in synthetic biology: problems and potential Pablo Schyfter As synthetic biology is a nascent research field, it is early enough to address the pervasive gender imbalance that has plagued the other natural sciences and engineering. Article 30 April 2020 EphA2 phosphorylates NLRP3 and inhibits inflammasomes in airway epithelial cells Ao Zhang Junji Xing Tianliang Xia Hua Zhang Mingli Fang Shibing Li Yong Du Xian C Li Zhiqiang Zhang Mu‐Sheng Zeng The tyrosine kinase receptor EphA2 functions as a negative regulator of inflammasome activation upon reovirus infection by targeting NLRP3 in airway epithelia. EphA2 also suppresses inflammatory responses in a murine ova‐induced asthma model. Article 29 April 2020 Distinct regulation of bioenergetics and translation by group I mGluR and NMDAR Sudhriti Ghosh Dastidar Shreya Das Sharma Sumita Chakraborty Sumantra Chattarji Aditi Bhattacharya Ravi S Muddashetty Protein synthesis within cortical neurons consumes a large fraction of cellular ATP. Glutamate receptors mGlulR and NMDAR modulate AMPK‐eEF2 signaling uniquely leading to dynamic regulation of protein synthesis and bioenergetics. Report 29 April 2020 The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila Jessica Leismann Mariangela Spagnuolo Mihika Pradhan Ludivine Wacheul Minh Anh Vu Michael Musheev Pablo Mier Miguel A Andrade‐Navarro Marc Graille Christof Niehrs Denis LJ Lafontaine Jean‐Yves Roignant This study identifies the Mettl5 Drosophila homolog as an m 6 A 18S rRNA methyltransferase required for normal walking behavior. Report 28 April 2020 MALT1 targeting suppresses CARD14‐induced psoriatic dermatitis in mice Elien Van Nuffel Jens Staal Griet Baudelet Mira Haegman Yasmine Driege Tino Hochepied Inna S Afonina Rudi Beyaert Expression of a pathogenic human CARD14 mutant transgene in keratinocytes is sufficient to drive psoriasis‐like dermatitis in mice, which can be inhibited by treatment with a MALT1 protease inhibitor. Science & Society 28 April 2020 Freedom of research in a democratic society Sebastian Wäscher Anna Deplazes‐Zemp Freedom of research and democratization of science are often conflicting concepts in democratic societies. It is thus necessary to define when either applies. view all latest online Article 23 March 2020 Role of respiratory NADH oxidation in the regulation of Staphylococcus aureus virulence Lici A Schurig‐Briccio Paola K Parraga Solorzano Andrea M Lencina Jana N Radin Grischa Y Chen John‐Demian Sauer Thomas E Kehl‐Fie Robert B Gennis NADH‐dependent respiration regulates fatty acid metabolism in Staphylococcus aureus . Changes in the concentration of free fatty acids are sensed by the SaeRS two‐component system, which controls virulence. Article 24 March 2020 OPEN ACCESS ECE2 regulates neurogenesis and neuronal migration during human cortical development Isabel Y Buchsbaum Pavel Kielkowski Grazia Giorgio Adam C O’Neill Rossella Di Giaimo Christina Kyrousi Shahryar Khattak Stephan A Sieber Stephen P Robertson Silvia Cappello Using in vitro and in vivo models of cortical development, this study identifies biallelic missense mutations in endothelin‐converting‐enzyme‐2 as novel candidates causative for the neuronal migration disorder periventricular heterotopia. Article 1 April 2020 Regulation of epidermal differentiation through KDF1‐mediated deubiquitination of IKKα Yuanyuan Li Liangfeng Tang Jiping Yue Xuewen Gou Anning Lin Scott D Weatherbee Xiaoyang Wu KDF1 (Keratinocyte Differentiation Factor 1) promotes the deubiquitination and stability of IKKα by recruiting USP7 (Ubiquitin Specific Peptidase 7). This interaction is essential for skin epidermal differentiation. Article 27 February 2020 Wip1 regulates Smad4 phosphorylation and inhibits TGF‐β signaling Dong‐Seok Park Gang‐Ho Yoon Eun‐Young Kim Taehyeong Lee Kyuhee Kim Peter CW Lee Eun‐Ju Chang Sun‐Cheol Choi Phosphorylation of Smad4, a central mediator of TGF‐β signaling, plays a pivotal role in controlling its activity and stability. Here, Wip1‐mediated dephosphorylation of Smad4 in its linker region is identified as a novel regulatory mechanism of TGF‐β signaling. Article 12 March 2020 OPEN ACCESS TLR4‐dependent shaping of the wound site by MSCs accelerates wound healing Saira Munir Abhijit Basu Pallab Maity Linda Krug Philipp Haas Dongsheng Jiang Gudrun...